Edward T. Kipreos, PhD, University of Georgia

Edward T. Kipreos, PhD
Edward T. Kipreos, PhD

The Kirpreos laboratory is interested in understanding how the cell cycle is regulated in the context of organismal development. They are using the nematode Caenorhabditis elegans as a model system. The adult C. elegans has only 959 somatic cells, yet has multiple tissues, including muscle, skin, neurons, and intestine. Somatic cell divisions are developmentally programmed and largely invariant, thereby allowing detailed analysis of individual cell divisions through development.

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References

  1. Brodigan, T.M., Liu, J., Park, M., Kipreos, E.T., and Krause, M. 2003. Cyclin E expression during development in C. elegans. Developmental Biology 254: 102-115.
  2. Kim, Y., and Kipreos, E.T. 2007. The C. elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Molecular and Cellular Biology 27: 1394-1406.
  3. The, I., Ruijtenberg, S., Bouchet, B. P., Cristobal, A., Prinsen, M. B., van Mourik, T., Koreth, J., Xu, H., Heck, A. J., Akhmanova, A., Cuppen, E., Boxem, M., Munoz, J., & van den Heuvel, S. (2015). Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nat Commun, 6, 5906.
  4. Fox, P. M., Vought, V. E., Hanazawa, M., Lee, M. H., Maine, E. M., & Schedl, T. (2011). Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development, 138 , 2223-34.
  5. Chiang, M., Cinquin, A., Paz, A., Meeds, E., Price, C. A., Welling, M., & Cinquin, O. (2015). Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation. BMC Biol, 13, 51.
  6. Korzelius, J., The, I., Ruijtenberg, S., Prinsen, M. B., Portegijs, V., Middelkoop, T. C., Groot, M. J. K., Holstege, F. C., Boxem, M., & van den Heuvel, S. (2011). Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. PLoS Genet, 7, e1002362.
  7. Friend, K., Campbell, Z. T., Cooke, A., Kroll-Conner, P., Wickens, M. P., & Kimble, J. (2012). A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Nat Struct Mol Biol, 19, 176-83.
  8. Peel, N., Dougherty, M., Goeres, J., Liu, Y., & O'Connell, K. F. (2012). The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci, 125, 3535-44.