Meenhard Herlyn, DVM, DSc, The Wistar Institute

Meenhard Herlyn, DVM, DSc
Meenhard Herlyn, DVM, DSc

The Herlyn Lab studies the normal and malignant tissue environment to develop rational approaches to cancer therapy. Their overall goals include: 1) Modeling the normal and diseased human tissue microenvironment, 2) Therapeutic targeting of signaling pathways in cancer, 3) Tumor dormancy and therapy resistance, and lastly 4) Stem cells and melanoma.

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References

  1. Folberg R, Donoso LA, Atkinson BF, Ernst CS, Herlyn M, Arbizo VV. An antimelanoma monoclonal antibody and the histopathology of uveal melanomas. Arch Ophthalmol. 1985 Feb;103(2):275-9. PubMed PMID: 2579631.
  2. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet. 1979 Nov;5(6):957-71.
  3. Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6833-7.
  4. Murthy U, Basu A, Rodeck U, Herlyn M, Ross AH, Das M. Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide. Arch Biochem Biophys. 1987 Feb 1;252(2):549-60.
  5. Herlyn D, Herlyn M, Ross AH, Ernst C, Atkinson B, Koprowski H. Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J ImmunolMethods. 1984 Oct 12;73(1):157-67.
  6. Ahmed M, Cheung NK. Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy. FEBS Lett. 2014 Jan 21;588(2):288-97.
  7. Herlyn M, Thurin J, Balaban G, Bennicelli JL, Herlyn D, Elder DE, Bondi E, Guerry D, Nowell P, Clark WH, et al. Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res. 1985 Nov;45(11 Pt 2):5670-6.
  8. Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T, Herlyn M. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell. 2010 May 14;141(4):583-94.