Richard B. Meagher, PhD, University of Georgia

Richard B. Meagher, PhD
Richard B. Meagher, PhD

Dr. Meagher's basic research has focused on the molecular cell biology of the actin cytoskeleton with a particular emphasis on the evolution and intereaction of genes and proteins in the ancient and divergent actin and actin binding protein gene families. Using the model plant Arabidopsis his group has shown that ancient subsets of actins, profilins, and actin deoplymerizing factor genes have co-evolved differential regulation in different organs and specialized interactions among protein variants in these organs.

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References

  1. Kandasamy, M.K., Gilliland, L.U., McKinney, E.C., and Meagher, R.B. (2001). One plant actin isovariant, ACT7, is induced by auxin and required for normal callus formation. Plant Cell 13, 1541-54.
  2. Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (1999). The late pollen-specific actins in angiosperms. Plant J 18, 681-91.
  3. Kandasamy, M.K., McKinney, E.C., Roy, E., and Meagher, R.B. (2012). Plant vegetative and animal cytoplasmic actins share functional competence for spatial development with protists. Plant Cell 24, 2041-57.
  4. Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2002). Plant profilin isovariants are distinctly regulated in vegetative and reproductive tissues. Cell Motil Cytoskeleton 52, 22-32.
  5. McKinney, E.C., Kandasamy, M.K., and Meagher, R.B. (2001). Small changes in the regulation of one arabidopsis profilin isovariant, PRF1, alter seedling development. Plant Cell 13, 1179-91.
  6. Kim T, Balish RS, Heaton AC, McKinney EC, Dhankher OP, Meagher RB. Engineering a root-specific, repressor-operator gene complex. Plant Biotechnol J. 2005 Nov;3(6):571-82.
  7. Müssar KJ, Kandasamy MK, McKinney EC, Meagher RB. Arabidopsis plants deficient in constitutive class profilins reveal independent and quantitative genetic effects. BMC Plant Biol. 2015 Jul 11;15:177.
  8. Rugh, Clayton L., Wilde, H. Dayton, Stack, Nicole M., Thompson, Deborah Marin, Summers, Anne O., and Meagher, Richard B. (1996) Mecuric ion reduction and resistance in transgenic Arabidopsis thaliana plants expressing a modified bacterial merA gene. Proc. Natl. Acad. Sci.USA, 93, 3182-3187.
  9. Nazaret, Sylvie, Jeffrey, Wade H., Saouter, Erwan, Von Haven, Robin, and Barkay, Tamar. (1994) merA Gene Expression in Aquatic Environments Measured by mRNA Production and Hg(II) Volatilization. Applied and Environmental Microbiology, Nov.1994, 4059-4065.
  10. Bizily, Scott P., Rugh, Clayton L., Summers, Anne O., and Meagher, Richard B. (1999). Phytoremediation of methylmercury pollution: merB expression in Arabidopsis thaliana confers resistance to organomercurials. Proc. Natl. Acad. Sci. USA. 96. 6808-6813.
  11. Kandasamy MK, McKinney EC, Meagher RB. ACTIN-RELATED PROTEIN8 encodes an F-box protein localized to the nucleolus in Arabidopsis. Plant Cell Physiol. 2008 May;49(5):858-63.
  12. Li Y, Kandasamy MK, Meagher RB. Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiol. 2001 Nov;127(3):711-9.
  13. Kandasamy MK, McKinney EC, Meagher RB. Differential sublocalization of actin variants within the nucleus. Cytoskeleton (Hoboken). 2010 Nov;67(11):729-43.
  14. Meagher RB, Kandasamy MK, Smith AP, McKinney EC. Nuclear actin-related proteins at the core of epigenetic control. Plant Signal Behav. 2010 May;5(5):518-22.
  15. Deal RB, Kandasamy MK, McKinney EC, Meagher RB. The nuclear actin-related protein ARP6 is a pleiotropic developmental regulator required for the maintenance of FLOWERING LOCUS C expression and repression of flowering in Arabidopsis. Plant Cell. 2005 Oct;17(10):2633-46.
  16. Deal RB, Topp CN, McKinney EC, Meagher RB. Repression of flowering in Arabidopsis requires activation of FLOWERING LOCUS C expression by the histone variant H2A.Z. Plant Cell. 2007 Jan;19(1):74-83.
  17. Li Y, Kandasamy MK, Meagher RB. Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiol. 2001 Nov;127(3):711-9. PubMed PMID: 11706154; PubMed Central PMCID: PMC1540151.
  18. LeBlanc MS, Lima A, Montello P, Kim T, Meagher RB, Merkle S. Enhanced arsenic tolerance of transgenic eastern cottonwood plants expressing gamma-glutamylcysteine synthetase. Int J Phytoremediation. 2011 Aug;13(7):657-73. PubMed PMID: 21972493.
  19. Li Y, Dhankher OP, Carreira L, Balish RS, Meagher RB. Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase. Environ Toxicol Chem. 2005 Jun;24(6):1376-86. PubMed PMID: 16117113.
  20. Dhankher OP, Li Y, Rosen BP, Shi J, Salt D, Senecoff JF, Sashti NA, Meagher RB. Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression. Nat Biotechnol. 2002 Nov;20(11):1140-5.
  21. Li Y, Kandasamy MK, Meagher RB. Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiol. 2001 Nov;127(3):711-9.
  22. LeBlanc MS, Lima A, Montello P, Kim T, Meagher RB, Merkle S. Enhanced arsenic tolerance of transgenic eastern cottonwood plants expressing gamma-glutamylcysteine synthetase. Int J Phytoremediation. 2011 Aug;13(7):657-73.
  23. Li Y, Dhankher OP, Carreira L, Balish RS, Meagher RB. Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase. Environ Toxicol Chem. 2005 Jun;24(6):1376-86.
  24. Dhankher OP, Li Y, Rosen BP, Shi J, Salt D, Senecoff JF, Sashti NA, Meagher RB. Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression. Nat Biotechnol. 2002 Nov;20(11):1140-5.
  25. Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant Cell Physiol. 2004 Dec;45(12):1787-97. Erratum in: Plant Cell Physiol. 2005 Feb;46(2):387.