Shu-Man Fu, MD, PhD, University of Virginia

Shu-Man Fu, MD
Shu-Man Fu, MD

The Fu laboratory studies the role that autoimmunity plays an in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The emphasis of the Fu laboratory is on the genetic and environmental factors important for these disorders.

The hypothesis that molecular mimicry initiates the initial autoimmune response, which diversifies to multiple autoantigens, resulting in end organ damage in suitable hosts is being tested. The role of MHC in this process in both mice and humans is being investigated. In this regard, bacterial and viral agents sharing cross reactive T and B cell epitopes with human autoantigens are logical candidates for molecular mimics in this process.

The Investigator's Annexe Part of The Investigator's Annexe program.

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Resources

  1. Gruber MF, Bjorndahl JM, Nakamura S, Fu SM. Anti-CD45 inhibition of human B cell profliferation depends on teh nature of activation signals and the state of B cell activation. J Immunol, 142(12):4144-4152, (1989).
  2. Bykowsky MJ, Haire RN, Ohta Y, Tang H, Sung SS, Veksler EG, Greene JM, Fu SM, Litman GW, Sullivan KE. Discordant phenotype in siblings with X-linked agammaglobulinemia. Am J Hum Genet, 58(3):477-483, (1996).