Terri Goss Kinzy, PhD, Rutgers University

Terri Goss Kinzy, PhD
Terri Goss Kinzy, PhD

The research in the Goss Kinzy laboratory is to understand the structural and functional basis of post-transcriptional mechanisms that regulate gene expression and targets of this process for fighting infectious diseases. They are applying complementary genetic, molecular, biochemical and structural techniques to dissect the mechanism of events occurring during protein synthesis. These include probing the physical and functional interaction of Elongations Factors (eEFs) with other factors that regulate gene expression and the interaction between the G-proteins in elongation with the ribosome.

Products

References

  1. Carr-Schmid A, Valente L, Loik VI, Williams T, Starita LM, Kinzy TG. Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity. Mol Cell Biol. 1999 Aug;19(8):5257-66.
  2. Anand M, Chakraburtty K, Marton MJ, Hinnebusch AG, Kinzy TG. Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3. J Biol Chem. 2003 Feb 28;278(9):6985-91. Epub 2002 Dec 18.
  3. Ortiz PA, Kinzy TG. Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast. Nucleic Acids Res. 2005 Oct 6;33(18):5740-8. Print 2005.
  4. Jørgensen, R, Carr-Schmid, A, Ortiz, PA, Kinzy, TG, Andersen, GR. Purification and crystallization of the yeast elongation factor eEF2. Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):712-5.