Chi-chung Hui, PhD, Hospital For Sick Children
Dr. Hui's laboratory is interested in iroquois homeodomain transcription factors. In humans and mice, there are six Iroquois homeobox (Irx) genes, which encode highly conserved TALE-class homeodomain containing transcription factors. Mutations in the human Irx4 and Irx5 genes have been found in congenital malformations with defects in heart and craniofacial development. My laboratory is using the mouse as a model to investigate the function of these Irx genes in embryonic development and adult physiology. Our genetic analysis revealed that the Irx genes possess unique as well as overlapping functions in both embryonic patterning and terminal differentiation. Ongoing studies are directed to decipher the molecular actions of these transcription factors in heart and limb development.
Part of The Investigator's Annexe program.
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References
- Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-MarÃn C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20;507(7492):371-5.
- Costantini DL, Arruda EP, Agarwal P, Kim K-H, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir G, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui C-c, Backx PH, Bruneau B. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21;123(2):347-58.
