H. Teresa Ku, PhD, City of Hope

H. Teresa Ku, PhD, City of Hope
H. Teresa Ku, PhD

Dr. Ku's research is focused on identification and characterization of pancreatic stem and progenitor cells, embryonic stem cell therapy for type 1 diabetes, and embryonic stem cells as a cellular tool for screening of molecules for treatment of diabetes. The Ku laboratory has established a quantitative and clonogenic progenitor cell assay, which will be a powerful tool to study the cellular and molecular mechanisms that govern the differentiation and proliferation of the pancreatic stem/progenitor cells at the single cell level.

The Investigator's Annexe Part of The Investigator's Annexe program.

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References:

  1. Winkler M, Trieu N, Feng T, Jin L, Walker S, Singh L, Ku HT. A quantitative assay for insulin-expressing colony-forming progenitors. J Vis Exp. 2011 Nov 28;(57):e3148.
  2. Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT .Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3907-12.
  3. Fu X, Jin L, Wang X, Luo A, Hu J, Zheng X, Tsark WM, Riggs AD, Ku HT, Huang W. (2013) MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A. 110:17892.
  4. Jin L, Feng T, Zerda R, Chen CC, Riggs AD, Ku HT.(2013) In vitro multi-lineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57Bl/6 mice. Stem Cells Dev. 2014 Apr 15;23(8):899-909.