Andrew D. Hollenbach, PhD, Louisiana State University Health Sciences Center
Andrew D. Hollenbach, PhD
The Hollenbach laboratory focuses on understanding how phosphorylation of the transcription factor Pax3 regulates its biological activity to control muscle and melanocyte development and how alteration of this activity contributes to the development of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS) and melanoma. The lab has identified the three sites of phosphorylation on Pax3, they have identified two of the three kinases responsible for phosphorylating these sites, and they have determined that the pattern of Pax3 phosphorylation changes significantly during the first eight hours of myogenesis.
Part of The Investigator's Annexe program.
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References
- Dietz KN, Miller PJ, Iyengar AS, Loupe JM, Hollenbach AD. Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation. Int J Biochem Cell Biol. 2011 Jun;43(6):936-45.
- Loupe JM, Miller PJ, Ruffin DR, Stark MW, Hollenbach AD. Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options. Oncogenesis. 2015 Mar 30;4:e145. doi: 10.1038/oncsis.2015.2.
