Geula Gibori, PhD, University of Illinois at Chicago

Geula Gibori
Guela Gibori, Ph.D.

Dr. Gibori laboratory research is aimed at defining the action and interaction of cytokines and estradiol on key ovarian and decidual genes whose expression is essential for the normal progress of pregnancy. Members of her laboratory have cloned several genes that play an essential role in the production of progesterone and estradiol. They are investigating their transcriptional regulation and are generating mice null in these genes. They have established that 17beta HSD, an enzyme involved in estradiol and cholesterol biosynthesis, is essential for brain development during pregnancy. They have also discovered, using knockout and knock-in mice, that PRL signaling through the short form of the PRL receptor (PRLRS) has a severe impact on ovarian follicular development and leads to premature ovarian failure and infertility. The cause of this pathology and the signaling mechanism of prolactin through PRLRS are under investigation. Another aspect of Dr. Gibori research activity is focused in defining the interaction and function of decidua-derived proteins in the normal development of the decidual tissue and the survival of fetuses.

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References

  1. Shehu A, Albarracin C, Devi YS, Luther K, Halperin J, Le J, Mao J, Duan RW, Frasor J, Gibori G. The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells. Mol Endocrinol. 2011 May;25(5):754-66.
  2. Duan WR, Parmer TG, Albarracin CT, Zhong L, Gibori G.PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum. Endocrinology. 1997 Aug;138(8):3216-21.
  3. Duan W.R., Linzer D.I.H., Gibori G. Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor.J. Biol. Chem. 271:15602-15607(1996).
  4. Parmer TG, McLean MP, Duan WR, Nelson SE, Albarracin CT, Khan I, Gibori G.Hormonal and immunological characterization of the 32 kilodalton ovarian-specific protein. Endocrinology 1992 Nov;131(5):2213-21.
  5. Mao J, Duan RW, Zhong L, Gibori G, Azhar S. Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase. Endocrinology. 1997 Jan;138(1):182-90.
  6. Albarracin CT, Parmer TG, Duan WR, Nelson SE, Gibori G. Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression Endocrinology. 1994 Jun;134(6):2453-60.
  7. Albarracin CT, Gibori G Prolactin action on luteal protein expression in the corpus luteum. Endocrinology. 1991 Oct;129(4):1821-30.
  8. Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y. Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. Endocrinology. 2007 Mar;148(3):976-88.