Anti-Tudor-SN (Tudor Staphylococcal Nuclease) [13.14.1] Antibody

This mouse IgG1k monoclonal antibody was raised against the C-terminal (amino acids 698-910) of, and is specific for human tudor staphylococcal nuclease (TUDOR-SN).

Highlights:

  • Reacts with human TUDOR-SN
  • Suitable for Western Blot applications

Tudor staphylococcal nuclease (Tudor-SN; TSN) is a highly conserved ?100-kDa protein that has four intact non-canonical staphylococcal nuclease domains and a Tudor domain. It is a subunit of the RNA-induced silencing complex, which is central to the mechanism of RNAi. Tudor-SN specifically interacts with and promotes cleavage of model hyper-edited dsRNA substrates containing multiple I·U and U·I pairs.

From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.

Catalog Number Product Size AVAILABILITY Price Qty
EWI035
Anti-Tudor-SN (Tudor Staphylococcal Nuclease) [13.14.1] Antibody
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: Tudor-SN (Tudor staphylococcal nuclease)
Accession ID: NCBI Gene ID: 38045
Molecular Weight: ~100 kDa
Isotype: IgG1k
Clonality: Monoclonal
Clone Name: 13.14.1
Reactivity: Human
Immunogen: C-term (aa698-910)
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB (1:1000)
Comments: Western blotting using anti-TSN confirmed that this protein bound only to affinity matrix I1 and did not bind to matrices G1 or G2
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.

References
  1. Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89. doi: 10.1016/j.cell.2013.03.024. PubMed PMID: 23622242; PubMed Central PMCID: PMC3651894.
  2. Scadden AD. The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage. Nat Struct Mol Biol. 2005 Jun;12(6):489-96. Epub 2005 May 15. PubMed PMID: 15895094

If you publish research with this product, please let us know so we can cite your paper.

 
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