Anti-Tudor-SN (Tudor Staphylococcal Nuclease) [13.14.1] Antibody
![Anti-Tudor-SN (Tudor Staphylococcal Nuclease) [13.14.1] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1674_2001202001265716730.jpg "Anti-Tudor-SN (Tudor Staphylococcal Nuclease) [13.14.1] Antibody")
This mouse IgG1k monoclonal antibody was raised against the C-terminal (amino acids 698-910) of, and is specific for human tudor staphylococcal nuclease (TUDOR-SN).
Highlights:
- Reacts with human TUDOR-SN
- Suitable for Western Blot applications
Tudor staphylococcal nuclease (Tudor-SN; TSN) is a highly conserved ?100-kDa protein that has four intact non-canonical staphylococcal nuclease domains and a Tudor domain. It is a subunit of the RNA-induced silencing complex, which is central to the mechanism of RNAi. Tudor-SN specifically interacts with and promotes cleavage of model hyper-edited dsRNA substrates containing multiple I·U and U·I pairs.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
This mouse IgG1k monoclonal antibody was raised against the C-terminal (amino acids 698-910) of, and is specific for human tudor staphylococcal nuclease (TUDOR-SN).
Highlights:
- Reacts with human TUDOR-SN
- Suitable for Western Blot applications
Tudor staphylococcal nuclease (Tudor-SN; TSN) is a highly conserved ?100-kDa protein that has four intact non-canonical staphylococcal nuclease domains and a Tudor domain. It is a subunit of the RNA-induced silencing complex, which is central to the mechanism of RNAi. Tudor-SN specifically interacts with and promotes cleavage of model hyper-edited dsRNA substrates containing multiple I·U and U·I pairs.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
Specifications
| Product Type: | Antibody |
| Antigen: | Tudor-SN (Tudor staphylococcal nuclease) |
| Accession ID: | Q9W0S7, 38045 |
| Molecular Weight: | ~100 kDa |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Clone Name: | 13.14.1 |
| Reactivity: | Human |
| Immunogen: | C-term (aa698-910) |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB (1:1000) |
| Comments: | Western blotting using anti-TSN confirmed that this protein bound only to affinity matrix I1 and did not bind to matrices G1 or G2 |
| Storage: | -20C |
| Shipped: | Cold Packs |
Provider
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
References
- Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89. doi: 10.1016/j.cell.2013.03.024. PubMed PMID: 23622242; PubMed Central PMCID: PMC3651894.
- Scadden AD. The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage. Nat Struct Mol Biol. 2005 Jun;12(6):489-96. Epub 2005 May 15. PubMed PMID: 15895094
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