Anti-ADAR1 [15.8.6] Antibody

This mouse IgG monoclonal antibody was raised against dsRNA binding domain (E2 to E8) of double-stranded RNA-specific adenosine deaminase (ADAR1) and recognizes human and mouse ADAR1.

Highlights:

  • Reacts with human and mouse ADAR1
  • Does not cross-react with different members of the ADAR family
  • Suitable for Western Blot, Immunohistochemistry and Immunostaining applications

ADAR/ADAR1 encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.

Catalog Number Product Size AVAILABILITY Price Qty
EWI036
Anti-ADAR1 [15.8.6] Antibody
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: ADAR1 (adenosine deaminase, RNA specific)
Accession ID: NCBI Gene ID: 103, Protein Accession No.: AAH38227
Molecular Weight: 110 kDa
Isotype: IgG
Clonality: Monoclonal
Clone Name: 15.8.6
Specificity: Native and Recombinant ADAR1; does not cross-react with different members of the ADAR family
Reactivity: Human and mouse
Immunogen: dsRNA binding domain (E2 to E8); raised against middle region (E2 to E8) of ADAR1 protein
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB, IHC, Immunostaining
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.

References
  1. Wang Q, Khillan J, Gadue P, Nishikura K. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science. 2000 Dec 1;290(5497):1765-8. PubMed PMID: 11099415.
  2. Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem. 2003 May 9;278(19):17093-102. Epub 2003 Mar 4. PubMed PMID: 12618436.

If you publish research with this product, please let us know so we can cite your paper.

 
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