Anti-Guinea pig GnRH [TF60] Antibody

This rabbit polyclonal antibody was generated against a peptide corresponding to Guinea pig Gonadotropin releasing hormone (GnRH) and recognizes Guinea pig GnRH.

Highlights:

  • Reacts with Guinea pig GnRH
  • No cross-reactivity with mammalian GnRH
  • Suitable for Radioimmuno assay (RIA) and Immunocytochemitry applications

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.

Catalog Number Product Size AVAILABILITY Price Qty
EUN001
Anti-Guinea pig GnRH [TF60] Antibody, 100uL
100uL In stock
Price: $299.00
Specifications
Product Type: Antibody
Name: Guinea pig GnRH [TF60] Antibody
Antigen: Extended Guinea pig GnRH
Clonality: Polyclonal
Immunogen: Extended Guinea pig GnRH (pGlu-Tyr-Trp-Ser-Tyr-Gly-Val-Arg-Pro-Gly-Lys) Available Here
Species Immunized: Rabbit
Buffer: Whole serum
Storage: -80C
Shipped: Dry Ice
Provider
From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.
References
  1. DANIELLE GROVE-STRAWSER, STACIA A. SOWER, PAUL M. RONSHEIM, JANE B. CONNOLLY, CARI G. BOURN, AND BEVERLY S. RUBIN. 2002. Guinea Pig GnRH: Localization and Physiological Activity Reveal That It, Not Mammalian GnRH, Is the Major Neuroendocrine Form in Guinea Pigs. Endocrinology 143 (5): 1602-1612.

If you publish research with this product, please let us know so we can cite your paper.

 
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