Anti-Cereblon (CRBN) [3B12F7] Antibody

This mouse IgG1k monoclonal antibody was generated against synthetic peptide and recognizes all mammals cereblon (CRBN).

Highlights:

  • Reacts with all mammalian CRBNs tested
  • Suitable for Western Blot and Immunohistochemistry applications

Protein cereblon is encoded by the CRBN, other names include AD-006 and MRT2A. It was originally identified as a genetic cause of inherited autosomal recessive mental retardation, the gene encodes a substrate receptor of a ubiquitin E3 cullin 4-RING ligase (CRL4) complex. CRBN also may play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning by its interaction with KCNT1. Also has been shown to be involved in pathway protein ubiquitination.

From the laboratory of David M. Lucas, PhD, The Ohio State University.

Catalog Number Product Size AVAILABILITY Price Qty
EF4007
Anti-Cereblon (CRBN) [3B12F7] Antibody, 100ug
100ug 3-5 weeks
Price: $275.00
Specifications
Product Type: Antibody
Antigen: Cereblon (CRBN, AD-006, MRT2A)
Accession ID: 51185 (Entrez Gene ID), Q96SW2 (UniProt)
Molecular Weight: 51 kDa
Isotype: IgG1k
Clonality: Monoclonal
Clone Name: 3B12F7
Reactivity: All mammals
Immunogen: KLH-conjugated linear peptide corresponding to a sequence near the N-terminus of human cereblon
Species Immunized: Mouse
Epitope: Available upon request
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB (1:1000), IHC (1:50)
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of David M. Lucas, PhD, Ohio State University.

References

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