Anti-Cadherin-1 [19A11] Antibody

This mouse IgG1 monoclonal antibody was generated against human E-cadherin (partial, amino acids 155-707) and recognizes human and dog cadherin-1 (CDH1).

Highlights:

  • Reacts with human and dog CDH1
  • Can bind human E-cadherin protein on the cell surface and activate the protein to stimulate strong cell-cell adhesion between tumor cells
  • Suitable for ELISA and Immunofluorescence, Immunocytochemistry, Western Blot and Immunoprecipitation applications

Cadherin-1 is a member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Mutations in this gene have been shown to associated with gastric, breast, colorectal, thyroid, and ovarian cancers.

From the laboratory of Barry M. Gumbiner, PhD, University of Virginia.

Catalog Number Product Size AVAILABILITY Price Qty
EG1010
Anti-Cadherin-1 [19A11] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Alternative Name(s): CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD_antigen: CD324
Antigen: Cadherin-1
Accession ID: P12830
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 19A11
Reactivity: Human and dog
Immunogen: Human E-cadherin (partial, amino acids 155-707)
Species Immunized: Mouse
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB, ELISA, IF(ICC), IP
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Barry M. Gumbiner, PhD, University of Virginia.

References
  1. Petrova YI, Spano MM, Gumbiner BM. Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell. 2012 Jun;23(11):2092-108.

If you publish research with this product, please let us know so we can cite your paper.

 
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