Anti-Complement C3b/C4b (CR1) [9H3] Antibody

This mouse IgG1 monoclonal antibody was generated against human complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35) and recognizes human CR1.

Highlights:

  • Reacts with human CR1
  • Recognizes human CR1 expressed on red cells and other cells
  • Suitable for ELISA and Immunofluorescence applications

The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. The CR1 gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The protein is involved in cellular binding to particles and immune complexes that have activated complement. Decreases in protein expression or mutations in the gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.

From the laboratory of Ronald P. Taylor, PhD, University of Virginia.

Catalog Number Product Size AVAILABILITY Price Qty
EG1009
Anti-Complement C3b/C4b (CR1) [9H3] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: Complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35)
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 9H3
Reactivity: Human
Immunogen: Human complement receptor 1
Species Immunized: Mouse
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: ELISA, IF
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.

References
  1. Ferguson PJ, Reist CJ, Martin EN, Johnson C, Greene KL, Kuhn S, Niebur J, Emlen W, Taylor RP. Antigen-based heteropolymers. A potential therapy for binding and clearing autoantibodies via erythrocyte CR1. Arthritis Rheum. 1995 Feb;38(2):190-200. PubMed PMID: 7848309.
  2. Hahn CS, French OG, Foley P, Martin EN, Taylor RP. Bispecific monoclonal antibodies mediate binding of dengue virus to erythrocytes in a monkey model of passive viremia. J Immunol. 2001 Jan 15;166(2):1057-65. PubMed PMID: 11145685.
  3. Craig ML, Waitumbi JN, Taylor RP. Processing of C3b-opsonized immune complexes bound to non-complement receptor 1 (CR1) sites on red cells: phagocytosis, transfer, and associations with CR1. J Immunol. 2005 Mar 1;174(5):3059-66. PubMed PMID: 15728520.

If you publish research with this product, please let us know so we can cite your paper.

 
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