Anti-Ceacam 1 [836/837] Antibody

This rabbit polyclonal antibody was generated against mouse carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) 6.5 kD long intracytoplasmic domain produced as a GST fusion protein, but cleaved from the GST.

Highlights:

  • Reacts with long intracytoplasmic domain of mouse CEACAM1 and mouse CEACAM2
  • Specific for mouse CEACAM1/2 intracytoplasmic domain; does not recognize other species
  • Suitable for Immunoprecipitation applications

CEACAM1 (biliary glycoprotein) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19 and the mouse CEACAM1 gene is located on mouse chr. 7. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

From the laboratory of Nicole Beauchemin, PhD, McGill University.

Catalog Number Product Size AVAILABILITY Price Qty
EMG007
Anti-Ceacam 1 [836/837] Antibody, 100uL
100uL In stock
Price: $299.00
Specifications
Product Type: Antibody
Antigen: CEACAM1
Accession ID: X67279
Molecular Weight: Native protein: CEACAM1-L (58 kDa), CEACAM1-S (54 kDa)
Glycosylated proteins so MW depends on the tissue: colon (120 kDa), liver (110 kDa), neutrophils (160 kDa)
Clonality: Polyclonal
Clone Name: 836/837
Reactivity: Mouse
Immunogen: Mouse CEACAM1 6.5 kD long intracytoplasmic domain produced as a GST fusion protein, but cleaved from the GST
Species Immunized: Rabbit
Epitope: Long intracytoplasmic domain of mouse CEACAM1 and mouse CEACAM2
Buffer: Serum
Tested Applications: IP (10 ul of Ab for IP of CEACAM1 from 1 mg of total lysate protein from transfected cells), Does not work well for Western Blots
Storage: -80C
Shipped: Dry Ice
Provider
From the laboratory of Nicole Beauchemin, PhD, McGill University.

References
  1. Rosenberg M, Nédellec P, Jothy S, Fleiszer D, Turbide C, Beauchemin N. The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues. Cancer Res. 1993 Oct 15;53(20):4938-45.

If you publish research with this product, please let us know so we can cite your paper.

 
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