Anti-Integrin alpha-IIb (ITGA2B) [Tab, 8aB5-9-9-15] Antibody

This mouse IgG1 monoclonal antibody (Tab) was raised against recombinant human platelets and is specific for human Integrin alpha-IIb subunit.

Highlights:

  • Recognizes human Integrin alpha-IIb subunit
  • Suitable for Flow Cytometry, Immunohistochemistry and Immunoprecipitation applications

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

From the laboratory of Rodger P. McEver, MD , Oklahoma Medical Research Foundation.

Catalog Number Product Size AVAILABILITY Price Qty
EOK005
Anti-Integrin alpha-IIb (ITGA2B) [Tab, 8aB5-9-9-15] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Alternative Name(s): Tab
Antigen: Integrin alpha-IIb subunit
Accession ID: P08514
Molecular Weight: 130 kDa
Isotype: IgG1
Clonality: Monoclonal
Clone Name: Tab, 8aB5-9-9-15
Reactivity: Human
Immunogen: Human platelets
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: Flow cytometry, IHC, IP
Storage: -20C
Shipped: Cold packs
Provider
From the laboratory of Rodger P. McEver, MD , Oklahoma Medical Research Foundation.
References
  1. McEver RP, Baenziger NL, Majerus PW. Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest. 1980 Dec;66(6):1311-8. PubMed PMID: 6449521
  2. McEver RP, Bennett EM, Martin MN. Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem. 1983 Apr 25;258(8):5269-75. PubMed PMID: 6220015.

If you publish research with this product, please let us know so we can cite your paper.

 
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