Anti-Apoptosis (FUS/TLS) [LHC7.15] Autoantibody
![Anti-Apoptosis (FUS/TLS) [LHC7.15] Autoantibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1560_2001202001265215590.jpg "Anti-Apoptosis (FUS/TLS) [LHC7.15] Autoantibody")
This mouse IgG2a monoclonal antibody recognizes human and mouse apoptosis RNA-binding protein FUS (FUS/TLS).
Highlights:
- Reacts with apoptotic cells; Binds DNA, RNA, and several known ribonucleoprotein autoantigens
- Upon induction of apoptosis, binds intensely to nuclei before nuclear fragmentation
- Antigen bound is differentially distributed between the nucleus and the cytoplasm in live and apoptotic cells
- Suitable for Western Blot and Immunofluorescence applications
RNA-binding protein FUS binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. It also has shown to play a role in maintenance of genomic integrity. FUS/TLS has been associated with liposarcoma, a cancer that arises in fat cells in deep soft tissue.
From the laboratory of Marko Radic, PhD, University of Tennessee.
This mouse IgG2a monoclonal antibody recognizes human and mouse apoptosis RNA-binding protein FUS (FUS/TLS).
Highlights:
- Reacts with apoptotic cells; Binds DNA, RNA, and several known ribonucleoprotein autoantigens
- Upon induction of apoptosis, binds intensely to nuclei before nuclear fragmentation
- Antigen bound is differentially distributed between the nucleus and the cytoplasm in live and apoptotic cells
- Suitable for Western Blot and Immunofluorescence applications
RNA-binding protein FUS binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. It also has shown to play a role in maintenance of genomic integrity. FUS/TLS has been associated with liposarcoma, a cancer that arises in fat cells in deep soft tissue.
From the laboratory of Marko Radic, PhD, University of Tennessee.
Specifications
| Product Type: | Antibody |
| Antigen: | hnRNP-P2-TLS, FUS |
| Accession ID: | NP_631888 |
| Molecular Weight: | 65 kDa |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | LHC7.15 |
| Reactivity: | Human and mouse |
| Immunogen: | NA (spontaneous) |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, IF |
| Storage: | -20C |
| Shipped: | Cold packs |
Provider
From the laboratory of Marko Radic, PhD, University of Tennessee.
References
- Radic MZ, Shah K, Zhang W, Lu Q, Lemke G, Hilliard GM. Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol. 2006 Jan 1;176(1):68-74.
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