Anti-HPV18, Protein E7 [HPV E7-99] Antibody
![Anti-HPV18, Protein E7 [HPV E7-99] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1557_2001202001265215560.jpg "Anti-HPV18, Protein E7 [HPV E7-99] Antibody")
This mouse monoclonal antibody was generated against E7 proteins of human papillomavirus type 18 (HPV18) and recognizes E7 protein of HPV18 and HPV16
Highlights:
- Readily detects HPV
- Reacts with E7 protein from HPV18 and HPV16
- Suitable for Western Blot, ELISA, Immunofluorescence, Immunohistochemistry applications
Protein E7 plays a role in HPV viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. E7 induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. E7 interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. E7 also plays a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
From the laboratory of A. Bennett Jenson, MD and Shin Je Ghim, PhD, University of Louisville.
This mouse monoclonal antibody was generated against E7 proteins of human papillomavirus type 18 (HPV18) and recognizes E7 protein of HPV18 and HPV16
Highlights:
- Readily detects HPV
- Reacts with E7 protein from HPV18 and HPV16
- Suitable for Western Blot, ELISA, Immunofluorescence, Immunohistochemistry applications
Protein E7 plays a role in HPV viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. E7 induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. E7 interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. E7 also plays a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
From the laboratory of A. Bennett Jenson, MD and Shin Je Ghim, PhD, University of Louisville.
| Product Type: | Antibody |
| Name: | Anti-HPV18, Protein E7 [HPV E7-99] Antibody |
| Accession ID: | NC_001357; P06788 |
| Antigen: | Major capsid protein of Human papillomavirus type 18 |
| Molecular Weight: | 17 kDa |
| Clonality: | Monoclonal |
| Clone Name: | HPV E7-99 |
| Reactivity: | Viral protein |
| Immunogen: | E7 proteins of HPV18 (E7 fusion Protein was cleaved and purified) |
| Species Immunized: | BALB/c mouse |
| Epitope: | Epitopes are on E7 of Both HPV16 and 18 |
| Purification Method: | Protein A/G Chromatography |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA, IF, immunohistochemistry |
| Storage: | -20C |
| Shipped: | Cold packs |
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