Anti-HPV18, Protein E7 [HPV E7-99] Antibody

This mouse monoclonal antibody was generated against E7 proteins of human papillomavirus type 18 (HPV18) and recognizes E7 protein of HPV18 and HPV16

Highlights:

  • Readily detects HPV
  • Reacts with E7 protein from HPV18 and HPV16
  • Suitable for Western Blot, ELISA, Immunofluorescence, Immunohistochemistry applications

Protein E7 plays a role in HPV viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. E7 induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. E7 interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. E7 also plays a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.

From the laboratory of A. Bennett Jenson, MD and Shin Je Ghim, PhD, University of Louisville.

Catalog Number Product Size AVAILABILITY Price Qty
EUL014
Anti-HPV18, Protein E7 [HPV E7-99] Antibody, 100ug
100ug 2-3 weeks
Price: $306.00
Specifications
Product Type: Antibody
Name: Anti-HPV18, Protein E7 [HPV E7-99] Antibody
Antigen: Major capsid protein of Human papillomavirus type 18
Accession ID: NC_001357; P06788
Molecular Weight: 17 kDa
Clonality: Monoclonal
Clone Name: HPV E7-99
Reactivity: Viral protein
Immunogen: E7 proteins of HPV18 (E7 fusion Protein was cleaved and purified)
Species Immunized: BALB/c mouse
Epitope: Epitopes are on E7 of Both HPV16 and 18
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB, ELISA, IF, immunohistochemistry
Purity: Protein A/G Chromatography
Storage: -20C
Shipped: Cold packs
Provider
From the laboratory of A. Bennett Jenson, MD and Shin Je Ghim, PhD, , University of Louisville.
References

If you publish research with this product, please let us know so we can cite your paper.

 
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