Anti-MAGE-A11 Antibodies

These rabbit IgG polyclonal antibodies were raised against purified FLAG-Melanoma-associated antigen 11 (MAGE-A11) protein expressed from baculovirus and recognize human MAGE-A11.

Highlights:

  • Recognize human MAGE-A11
  • Suitable for Western Blot applications

MAGE-A11 acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

From the laboratory of Elizabeth M. Wilson, PhD , University of North Carolina at Chapel Hill.

Catalog Number Product Size AVAILABILITY Price Qty
ENC003
Anti-MAGE-A11 [20493] Antibody
100uL In stock
Price: $306.00
ENC004
Anti-MAGE-A11 [20494] Antibody
100uL In stock
Price: $306.00
Specifications
Product Type: Antibody
Antigen: MAGE-A11
Accession ID: GenBank accession no. NP-005357, NCBI Reference Sequence: NP_005357.2, UniProt: P43364
Molecular Weight: Calculated mol wt = 47,998 Da, SDS gel migration = ~58 kDa
Isotype: IgG
Clonality: Polyclonal
Clone Name: MAGE-A11-1 rabbit 100, MAGE-A11-2 rabbit 20494
Reactivity: Human
Immunogen: Purified FLAG-MAGE-A11 protein expressed from baculovirus
Species Immunized: Rabbit
Purification Method: Unpurified serum. Pierce Melon column recommended for further purification.
Buffer: Serum
Tested Applications: WB (0.1 µg/ml for ectopic MAGE-A11 expression to 10 µg/ml for endogenous MAGE-A11)
Comments: MAGE-A11-1 antibody also reacts with FLAG tag , MAGE-A11-2 antibody does not react with FLAG tag
Storage: -80C
Shipped: Dry Ice
Provider
From the laboratory of Elizabeth M. Wilson, PhD, University of North Carolina at Chapel Hill.
References
  1. Askew EB, Bai S, Hnat AT, Minges JT, Wilson EM 2009 Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J Biol Chem 284:34793-34808.
  2. Askew EB, Bai S, Blackwelder AJ, Wilson EM 2010 Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J Biol Chem 285:21824-21836.
  3. Su S, Blackwelder AJ, Grossman G, Minges JT, Yuan L, Young SL, Wilson EM 2012 Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. J Biol Chem 287:34809-34824.
  4. Minges JT, Su S, Grossman G, Blackwelder AJ, Pop EA, Mohler JL, Wilson EM 2013 Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. J Biol Chem 288:1939-1952.
  5. Su S, Minges JT, Grossman G, Blackwelder AJ, Mohler JL, Wilson EM 2013 Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem 288:24809-24824.
  6. Minges JT, Grossman G, Zhang P, Kafri T, Wilson EM 2015 Post-translational down-regulation of melanoma antigen-A11 (MAGE-A11) by human p14-ARF tumor suppressor. J Biol Chem 290:25174-25187.

If you publish research with this product, please let us know so we can cite your paper.

 
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