Anti-CPG2 Antibodies

These mouse monoclonal antibodies were raised against peptide and recognize mouse and rat candidate plasticity protein 2b (CPG2).

Highlights:

  • Recognizes mouse and rat CPG2
  • Specific to the clathrin-coated pits in the postsynaptic zone in glutamatergic synapses
  • Unique specificity enables high-resolution imaging of glutamatergic synapses, in contrast to antibodies to other proteins such as PSD-95 that are expressed in other synaptic sites
  • Suitable for Western Blot, Immunohistochemistry, and Immunoprecipitation applications

Candidate plasticity protein 2 (CPG2) is a protein that is regulated by neuronal activity in the rodent brain. CPG2 is uniquely expressed in the postsynaptic zones of glutamatergic (excitatory) synapses, so antibodies to CPG2 would be an excellent tool for studying excitatory synaptic activity in mice and rats.

From the laboratory of Elly Nedivi, PhD, Massachusetts Institute of Technology.

Catalog Number Product Size AVAILABILITY Price Qty
EC0003
Anti-CPG2 [200A5] Antibody
100ug 3-5 weeks
Price: $306.00
EC0004
Anti-CPG2 [200A6] Antibody
100ug 3-5 weeks
Price: $306.00
EC0005
Anti-CPG2 [200A9] Antibody
100ug 3-5 weeks
Price: $306.00
Specifications
Name: Candidate plasticity protein 2 (CPG2) Antibodies
Antigen: CPG2
Accession ID: Q6PLD8
Isotype: IgG2a (200A5, 200A9); IgG1 (200A6)
Clonality: Monoclonal
Clone Name: 200A5, 200A6, 200A9
Reactivity: Mouse, Rat
Immunogen: Peptide (RKLESTLTGLEQSRERQERR)
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB, IHC, IP
Storage: -20C
Shipped: Cold packs
Data

CPG2 Stain Of Postsynaptic Glutamatergic Synapses

Individual spines from cultured neurons stained for actin filaments (green), CPG2 (red), and PSD-95 (blue). Scale bar, 1 um.

Adapted from: Cottrell JR et al., Neuron. 2004 Nov 18;44(4):677-90.
Provider
From the laboratory of Elly Nedivi, PhD, Massachusetts Institute of Technology.
References
  1. Cottrell JR, Borok E, Horvath TL, Nedivi E. CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron. 2004 Nov 18;44(4):677-90. PubMed PMID: 15541315; PubMed Central PMCID: PMC3065105.

If you publish research with this product, please let us know so we can cite your paper.

 
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