Anti-Cullin-4A (CUL4A) Antibody
This rabbit polyclonal antibody was generated against a chemically synthesized peptide, with the sequence ERDKDNPNQYHYVA, corresponding to human Cullin-4A (CUL4A) and recognizes human and mouse CUL4A.
Highlights:
- Recognizes human and mouse CUL4a
- Suitable for Immunohistochemistry, Immunofluorescence and Western Blot applications
CUL4A belongs to the cullin family of ubiquitin ligase proteins. It is a core component of multiple cullin-RING-based E3 ubiquitin protein ligase complexes, which mediate the ubiquitination of target proteins. Cul4A is highly homologous to the CUL4B protein. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. Some of the specific CUL4A substrates are p53, DDB2, p21, Cdt1 and HOXA9. CUL4A regulates numerous key processes such as DNA repair, cellular proliferation, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. CUL4A deregulation plays role in viral pathogenesis and carcinogenesis. Cul4A gene has been found amplified in many cancers.
From a laboratory at University of Illinois at Chicago.
This rabbit polyclonal antibody was generated against a chemically synthesized peptide, with the sequence ERDKDNPNQYHYVA, corresponding to human Cullin-4A (CUL4A) and recognizes human and mouse CUL4A.
Highlights:
- Recognizes human and mouse CUL4a
- Suitable for Immunohistochemistry, Immunofluorescence and Western Blot applications
CUL4A belongs to the cullin family of ubiquitin ligase proteins. It is a core component of multiple cullin-RING-based E3 ubiquitin protein ligase complexes, which mediate the ubiquitination of target proteins. Cul4A is highly homologous to the CUL4B protein. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. Some of the specific CUL4A substrates are p53, DDB2, p21, Cdt1 and HOXA9. CUL4A regulates numerous key processes such as DNA repair, cellular proliferation, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. CUL4A deregulation plays role in viral pathogenesis and carcinogenesis. Cul4A gene has been found amplified in many cancers.
From a laboratory at University of Illinois at Chicago.
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| Product Type: | Antibody |
| Antigen: | Cul4A |
| Accession ID: | Q13619 |
| Molecular Weight: | 80 kDa |
| Clonality: | Polyclonal |
| Reactivity: | Human and mouse |
| Immunogen: | Chemically synthesized peptide, with the sequence ERDKDNPNQYHYVA, corresponding to human CUL-4A, conjugated to maleimide-activated keyhole limpet hemocyanin |
| Species Immunized: | Rabbit |
| Buffer: | Serum |
| Tested Applications: | WB, IF, IHC |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of G? as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. 2015 Jun 4;58(5):794-803.
- Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, Raychaudhuri P. Proliferation defects and genome instability in cells lacking Cul4A. 2009 Jul 2;28(26):2456-65.
- Kopanja D, Roy N, Stoyanova T, Hess RA, Bagchi S, Raychaudhuri P. Cul4A is essential for spermatogenesis and male fertility. 2011 Apr 15;352(2):278-87.
- Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, Raychaudhuri P. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006 Apr;26(7):2531-9.
- Nag A, Bagchi S, Raychaudhuri P. Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res. 2004 Nov 15;64(22):8152-5.
- Shiyanov P, Nag A, Raychaudhuri P. Cullin 4A associates with the UV-damaged DNA-binding protein DDB. J Biol Chem. 1999 Dec 10;274(50):35309-12.
- Nag A, Bondar T, Shiv S, Raychaudhuri P. The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol Cell Biol. 2001 Oct;21(20):6738-47.
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