Anti-TLR3, Extracellular Domain [11F8.1B7] Antibody

This rat IgG2a monoclonal antibody was generated against purified recombinant protein and is specific for mouse Toll-like receptor 3 (TLR3) extracellular domain.

Highlights:

  • Recognizes mouse TLR3 extracellular domain
  • Suitable for Immunhistochemistry and Flow Cytometry applications

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein part of the toll receptor family involved in the innate immune system. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes It induces the activation of IRF3 an the production of type 1 interferos.

From the laboratory of David M. Segal, PhD, National Cancer Institute/NIH.

Catalog Number Product Size AVAILABILITY Price Qty
ENH037
Anti-TLR3, Extracellular Domain [11F8.1B7] Antibody, 100ug
100ug 3-5 weeks
Price: $306.00

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Specifications
Product Type: Antibody
Antigen: Mouse TLR3 extracellular domain
Accession ID: Q99MB1
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: 11F8.1B7
Reactivity: Mouse
Immunogen: Purified recombinant protein
Species Immunized: Rat
Epitope: Extracellular domain
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB, ELISA, IF, IB
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of David M. Segal, PhD, National Cancer Institute/NIH.
References
  1. McCartney S, Vermi W, Gilfillan S, Cella M, Murphy TL, Schreiber RD, Murphy KM, Colonna M. Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med. 2009 Dec 21;206(13):2967-76.
  2. Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM. TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection. J Immunol. 2011 Feb 15;186(4):2422-9.
  3. McCartney SA, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, Gilfillan S, Diamond MS, Unanue ER, Colonna M. RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. J Clin Invest. 2011 Apr;121(4):1497-507.
  4. Azuma M, Ebihara T, Oshiumi H, Matsumoto M, Seya T. Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells. Oncoimmunology. 2012 Aug 1;1(5):581-592.
  5. Zeng R, Bscheider M, Lahl K, Lee M, Butcher EC. Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid. Mucosal Immunol. 2016 Jan;9(1):183-93.

If you publish research with this product, please let us know so we can cite your paper.

 
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