Anti-Ganglioside GD2 [ME361] Antibody
![Anti-Ganglioside GD2 [ME361] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1179_2001202001263711780.jpg "Anti-Ganglioside GD2 [ME361] Antibody")
This mouse IgG monoclonal antibody recognizes human ganglioside GD2.
Highlights:
- Specific for human ganglioside GD2
- Has low affinity for GD3 a surface marker present on several neuroectodermal tumors including melanoma
- ME 36.1 has been found to inhibit tumor growth at the inoculation site as well as metastatic spread to lymph nodes and lungs in preclinical studies
- Suitable for FACS, Immunohistochemistry and Binding Assay applications
Ganglioside GD2, is a sialic acid-containing glycosphingolipid involved in cell attachment to the extracellular matrix. GD2 is overexpressed on neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors, osteosarcoma, rhabdomyosarcoma tissues. GD2 localizes to the cell surface. GD2 has been shown to enhance tumor proliferation and invasiveness in osteosarcoma and small cell lung cancer cells.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
This mouse IgG monoclonal antibody recognizes human ganglioside GD2.
Highlights:
- Specific for human ganglioside GD2
- Has low affinity for GD3 a surface marker present on several neuroectodermal tumors including melanoma
- ME 36.1 has been found to inhibit tumor growth at the inoculation site as well as metastatic spread to lymph nodes and lungs in preclinical studies
- Suitable for FACS, Immunohistochemistry and Binding Assay applications
Ganglioside GD2, is a sialic acid-containing glycosphingolipid involved in cell attachment to the extracellular matrix. GD2 is overexpressed on neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors, osteosarcoma, rhabdomyosarcoma tissues. GD2 localizes to the cell surface. GD2 has been shown to enhance tumor proliferation and invasiveness in osteosarcoma and small cell lung cancer cells.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Antibody |
| Antigen: | Ganglioside GD2 |
| Accession ID: | CAS Number 65988-71-8; bDGalpNAc(1-4)[aNeu5Ac(2-8)aNeu5Ac(2-3)]bDGalp(1-4)bDGlcp(1-1)Cer |
| Isotype: | IgG2a/kappa |
| Clonality: | Monoclonal |
| Clone Name: | ME361 / ME36.1 |
| Reactivity: | Human |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | FACS (1:50), IHC (1:50), Binding assays (1:50) |
| Storage: | -20C |
| Shipped: | Cold packs |
Provider
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
References
- Ahmed M, Cheung NK. Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy. FEBS Lett. 2014 Jan 21;588(2):288-97.
- Herlyn M, Thurin J, Balaban G, Bennicelli JL, Herlyn D, Elder DE, Bondi E, Guerry D, Nowell P, Clark WH, et al. Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res. 1985 Nov;45(11 Pt 2):5670-6.
- Iliopoulos, D; Ernst, C; Steplewski, Z; Jambrosic, J A; Rodeck, U; Herlyn, M; Clark, W H; Koprowski, H; Herlyn, D. Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides.J Natl Cancer Inst. 1989 03 15;81(6):440-4
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- Agostino, Mark; Yuriev, Elizabeth; Ramsland, Paul A. Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping.PLoS One. 2012;7(4):e35457
- Ahmed, Mahiuddin; Goldgur, Yehuda; Hu, Jian; Guo, Hong-Fen; Cheung, Nai-Kong V. In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors.PLoS One. 2013;8(5):e63359
- Cheung, Nai-Kong V; Guo, Hongfen; Hu, Jian; Tassev, Dimiter V; Cheung, Irene Y. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo.Oncoimmunology. 2012 07 01;1(4):477-486
- Bernhard, H; Karbach, J; Strittmatter, W; Meyer Zum Büschenfelde, K H; Knuth, A. Induction of tumor-cell lysis by bi-specific antibody recognizing ganglioside GD2 and T-cell antigen CD3.Int J Cancer. 1993 09 30;55(3):465-70
- Ruf, Peter; Schäfer, Beatrix; Eissler, Nina; Mocikat, Ralph; Hess, Juergen; Plöscher, Matthias; Wosch, Susanne; Suckstorff, Ivonne; Zehetmeier, Christine; Lindhofer, Horst. Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model.J Transl Med. 2012 11 07;10:219
- Kieber-Emmons, Thomas; Saha, Somdutta; Pashov, Anastas; Monzavi-Karbassi, Behjatolah; Murali, Ramachandran. Carbohydrate-mimetic peptides for pan anti-tumor responses.Front Immunol. 2014;5:308
- Wondimu, Assefa; Zhang, Tianqian; Kieber-Emmons, Thomas; Gimotty, Phyllis; Sproesser, Katrin; Somasundaram, Rajasekharan; Ferrone, Soldano; Tsao, Chun-Yen; Herlyn, Dorothee. Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice.Cancer Immunol Immunother. 2008 07;57(7):1079-89
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