Anti-EGFR [425] Antibody
![Anti-EGFR [425] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1176_2001202001263711750.jpg "Anti-EGFR [425] Antibody")
This mouse IgG monoclonal antibody was generated against A431 carcinoma cells and recognizes human epidermal growth factor receptor (EGFR).
Highlights:
- Specific for human EGFR
- Recognizes the active form of EGFR in both glycosylated and non-glycosylated EGFR
- Suitable for Western Blot applications
EGFR is a cell surface protein that binds to epidermal growth factor as well as transforming growth factor alpha (TGFa). It is a member of the epidermal growth factor family and is closely related to receptor tyrosine kinases. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme as well as inflammatory diseases.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
This mouse IgG monoclonal antibody was generated against A431 carcinoma cells and recognizes human epidermal growth factor receptor (EGFR).
Highlights:
- Specific for human EGFR
- Recognizes the active form of EGFR in both glycosylated and non-glycosylated EGFR
- Suitable for Western Blot applications
EGFR is a cell surface protein that binds to epidermal growth factor as well as transforming growth factor alpha (TGFa). It is a member of the epidermal growth factor family and is closely related to receptor tyrosine kinases. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme as well as inflammatory diseases.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | EGFR |
| Accession ID: | P00533 |
| Molecular Weight: | 170 kDa |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | 425 |
| Reactivity: | Human |
| Immunogen: | A431 carcinoma cells |
| Species Immunized: | Mouse |
| Epitope: | Epitope is not known, but closely linked to the EGF binding active site, as the antibody only recognizes the active form of EGFR |
| Buffer: | Ascites |
| Tested Applications: | WB (1:1000) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Murthy U, Basu A, Rodeck U, Herlyn M, Ross AH, Das M. Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide. Arch Biochem Biophys. 1987 Feb 1;252(2):549-60.
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