Anti-Influenza A (H1N1) Cal/09, H1 Hemagglutinin (HA) [7B2-32] Antibody
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This mouse IgG2b monoclonal antibody was generated against virus and is specific for head domain of 195 A/California/04/2009 (Cal/09) Hemagglutinin (HA) H1N1 influenza virus.
Highlights
- Reacts with H1 HA of influenza virus, A/California/4/2009 (H1N1)
- Suitable for ELISA, Hemagglutination Inhibition Assays, Immunofluorescence and Western Blot applications
Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) outbreaks in 2009 as well as 1918. H1N1 is an orthomyxovirus because it contains the glycoproteins haemagglutinin and neuraminidase. Haemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. In Neuraminidase are a type of glycoside hydrolase enzyme which help to move the virus particles through the infected cell and assist in budding from the host cells.
From the laboratories of Peter Palese, PhD, Adolfo Garcia-Sastre, PhD, Christopher F. Basler, PhD, Thomas M. Moran, PhD, Icahn School of Medicine at Mount Sinai.
This mouse IgG2b monoclonal antibody was generated against virus and is specific for head domain of 195 A/California/04/2009 (Cal/09) Hemagglutinin (HA) H1N1 influenza virus.
Highlights
- Reacts with H1 HA of influenza virus, A/California/4/2009 (H1N1)
- Suitable for ELISA, Hemagglutination Inhibition Assays, Immunofluorescence and Western Blot applications
Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) outbreaks in 2009 as well as 1918. H1N1 is an orthomyxovirus because it contains the glycoproteins haemagglutinin and neuraminidase. Haemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. In Neuraminidase are a type of glycoside hydrolase enzyme which help to move the virus particles through the infected cell and assist in budding from the host cells.
From the laboratories of Peter Palese, PhD, Adolfo Garcia-Sastre, PhD, Christopher F. Basler, PhD, Thomas M. Moran, PhD, Icahn School of Medicine at Mount Sinai.
| Product Type: | Antibody |
| Name: | Influenza HA 2009 (H1) |
| Accession ID: | P03454 |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | 7B2-32 |
| Reactivity: | Virus |
| Immunogen: | Virus |
| Species Immunized: | Mouse |
| Epitope: | Head domain of 195 A/California/04/2009 (Cal/09) Hemagglutinin (HA) |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | ELISA, Hemagglutination Inhibition Assays, IF, WB |
| Storage: | -20C |
| Shipped: | Cold packs |
- Tran EE, Podolsky KA, Bartesaghi A, Kuybeda O, Grandinetti G, Wohlbold TJ, TanGS, Nachbagauer R, Palese P, Krammer F, Subramaniam S. Cryo-electron MicroscopyStructures of Chimeric Hemagglutinin Displayed on a Universal Influenza VaccineCandidate. MBio. 2016 Mar 22;7(2). pii: e00257-16. doi: 10.1128/mBio.00257-16.
- DiLillo DJ, Tan GS, Palese P, Ravetch JV. Broadly neutralizing hemagglutininstalk-specific antibodies require Fc?R interactions for protection againstinfluenza virus in vivo. Nat Med. 2014 Feb;20(2):143-51. doi: 10.1038/nm.3443.Epub 2014 Jan 12.
- Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P. A pan-H1anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy invivo. J Virol. 2012 Jun;86(11):6179-88. doi: 10.1128/JVI.00469-12.
- Retamal M, Abed Y, Corbeil J, Boivin G. Epitope mapping of the 2009 pandemicand the A/Brisbane/59/2007 seasonal (H1N1) influenza virus haemagglutinins using mAbs and escape mutants. J Gen Virol. 2014 Nov;95(Pt 11):2377-89. doi:10.1099/vir.0.067819-0.
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