Anti-CD20, N-Terminal [1439] Antibody
![Anti-CD20, C-Terminal [1439] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1094_2001202001263410930.jpg "Anti-CD20, N-Terminal [1439] Antibody")
This rabbit polyclonal antibody [1439] was generated against a synthetic peptide corresponding to residues 25-41 (SGPKPLFRRMSSLVGPT) of human CD20 conjugated to ovalbumin, and is specific for the intracellular N-terminal region of human CD20.
Highlights:
- Reacts with intracellular N-terminal residues 25-41 of human CD20
- Valuable for both pre-clinical and clinical research applications
- Suitable for Western Blot applications
CD20, or B-lymphocyte antigen CD20, is a cell-surface protein expressed in most immune cells arising from the B-cell lineage and plays a role in cellular activation and proliferation. Importantly, CD20 is a recognized biomarker for a number of human disorders, including several autoimmune diseases and B-cell malignancies.
From the laboratory of Julie P. Deans, PhD, University of Calgary.
Part of The Investigator's Annexe program.
This rabbit polyclonal antibody [1439] was generated against a synthetic peptide corresponding to residues 25-41 (SGPKPLFRRMSSLVGPT) of human CD20 conjugated to ovalbumin, and is specific for the intracellular N-terminal region of human CD20.
Highlights:
- Reacts with intracellular N-terminal residues 25-41 of human CD20
- Valuable for both pre-clinical and clinical research applications
- Suitable for Western Blot applications
CD20, or B-lymphocyte antigen CD20, is a cell-surface protein expressed in most immune cells arising from the B-cell lineage and plays a role in cellular activation and proliferation. Importantly, CD20 is a recognized biomarker for a number of human disorders, including several autoimmune diseases and B-cell malignancies.
From the laboratory of Julie P. Deans, PhD, University of Calgary.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | CD20 (CD20-N) |
| Accession ID: | P11836 |
| Molecular Weight: | 33-35 kDa |
| Clonality: | Polyclonal |
| Clone Name: | 1439 |
| Reactivity: | Human |
| Immunogen: | Peptide conjugated to ovalbumin |
| Species Immunized: | Rabbit |
| Epitope: | N-terminal residues 25-41; SGPKPLFRRMSSLVGPT |
| Buffer: | Serum |
| Tested Applications: | WB (1:10,000), IP |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Western Blot of CD20 N and C-terminus
Western blots of human Ramos B-cells lysates probed with rabbit anti-CD20N (targeting the N-terminal residues 25-41) and rabbit anti-CD20C (targeting the C-terminal residues 231-245), pre-incubated with immunizing peptide (lanes 2 and 5), irrelevant peptide (lanes 3 and 6) or no peptide (lanes 1 and 4).
Adapted from: Polyak MJ, et al. J Immunol. 1998 Oct 1;161(7):3242-8.
- Polyak MJ, Tailor SH, Deans JP. Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment. J Immunol. 1998 Oct 1;161(7):3242-8.
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