Human Pancreatic Duct Epithelial Cell Line (H6c7)

H6c7 is an immortalized epithelial cell line derived from normal human pancreatic duct epithelial (HPDE) cells. This cell line is an attractive model for human pancreatic duct cell carcinogenesis studies.

Highlights

  • Demonstrate near normal genotype and phenotype of HPDE cells
  • Display copy number of p16INK4A gene, wild type p53 and KRAS genes
  • Morphologically similar to the primary HPDE cells, grow anchorage-dependently and do not form tumors in scid mice
  • Growth remains inhibited by transforming growth factor (TGF)-beta 1

From the laboratory of Ming-Sound Tsao, MD, FRCPC, University Health Network, Canada.

Catalog Number Product Size AVAILABILITY Price Qty
ECA001
Human Pancreatic Duct Epithelial Cell Line (H6c7), 1 Vial
1 vial 3-4 weeks
Price: $799.00

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Specifications
Name: H6C7
Cell Type: Epithelial
Organism: Human
Accession ID: CVCL_0P38
Morphology: Epithelial
Biosafety Level: BSL1
Subculturing: 1:4 split
Growth Conditions: Keratinocyte serum free
Cryopreservation: Growth medium plus 10% DMSO
Source: Pancreatic duct
Mycoplasma Tested: Yes
Storage: Liquid nitrogen
Shipped: Dry ice
Documentation
Provider
From the laboratory of Ming-Sound Tsao, MD, FRCPC, University Health Network, Canada.
References
  1. Radulovich N, Qian JY, Tsao MS. Human pancreatic duct epithelial cell model for KRAS transformation. Methods Enzymol. 2008;439:1-13.
  2. Qian J, Niu J, Li M, Chiao PJ, Tsao MS. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res. 2005 Jun 15;65(12):5045-53.
  3. Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA, Tsao MS. Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol. 1996 Jun;148(6):1763-70.

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