Anti-Von Willebrand Factor [3E2] Antibody
![Anti-Von Willebrand Factor [3E2] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/771_200120200126217700.jpg "Anti-Von Willebrand Factor [3E2] Antibody")
This mouse monoclonal antibody was generated against purified native von Willebrand Factor (vWF) and recognizes human vWF.
Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis. It promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. vWF also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and hemolytic-uremic syndrome.
From the laboratory of David A. Fox, MD, University of Michigan.
Part of The Investigator's Annexe program.
This mouse monoclonal antibody was generated against purified native von Willebrand Factor (vWF) and recognizes human vWF.
Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis. It promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. vWF also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and hemolytic-uremic syndrome.
From the laboratory of David A. Fox, MD, University of Michigan.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | von Willebrand Factor (vWF) |
| Accession ID: | P04275 |
| Molecular Weight: | >300 kDa |
| Isotype: | IgG1 kappa |
| Clonality: | Monoclonal |
| Clone Name: | 3 E2 |
| Reactivity: | Human |
| Immunogen: | Purified native von Willebrand Factor |
| Species Immunized: | Mouse |
| Purification Method: | Protein G column |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB (1:500) |
| Concentration: | 1 mg/mL |
| Storage: | -20C |
| Shipped: | Cold packs |
- Ginsburg D, Bockenstedt PL, Allen EA, Fox DA, Foster PA, Ruggeri ZM, Zimmerman TS, Montgomery RR, Bahou WF, Johnson TA, et al. Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. Thromb Haemost. 1992 Jan 23;67(1):166-71.
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