Anti-SNF2-Related -CBP-Activator Protein (SRCAP) Antibody (Serum)
This antibody was raised in rabbits against a recombinant human protein of SRCAP corresponding to the C-terminal 200 amino acids. It is recommended for detection of human, mouse and rat SRCAP by WB.
The SRCAP (SNF2-Related-CBP-Activator Protein) gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features.
From the laboratory of John Chrivia, PhD, St. Louis University.
Part of The Investigator's Annexe program.
This antibody was raised in rabbits against a recombinant human protein of SRCAP corresponding to the C-terminal 200 amino acids. It is recommended for detection of human, mouse and rat SRCAP by WB.
The SRCAP (SNF2-Related-CBP-Activator Protein) gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features.
From the laboratory of John Chrivia, PhD, St. Louis University.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | SRCAP |
| Accession ID: | Q6ZRS2, NP_006653 |
| Molecular Weight: | 400 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | SLU2 |
| Reactivity: | Human, mouse, and rat |
| Immunogen: | Peptide |
| Species Immunized: | Rabbit |
| Epitope: | C-terminal 200 amino acids of SRCAP |
| Purification Method: | Crude serum |
| Buffer: | Normal rabbit serum |
| Tested Applications: | WB (1:1000-5000) |
| Amount: | 100uL |
| Storage: | -80C |
| Shipped: | Cold packs |
Western Blot Analysis.
Western blot analysis of A549 nuclear extracts were performed using anti-p400 antibody (SLU3) or in the right panel using anti-SRCAP antibody (SLU2).
- The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. (2007). Wong, M.M., Cox L.K. and Chrivia, J.C. (2007). J Biol Chem. 282, 26132-26139.
- Purification of a Human SRCAP Complex that Remodels Chromatin by Incorporating the Histone Variant H2A.Z into Nucleosomes. (2006). Ruhl, D.D., Jin, J. Cai, Y. Swanson, S., Florens, L., Michael P. Washburn, M.P., Conaway, R. and Conaway, J.W. and Chrivia, J.C.. Biochemistry 45, 5671-5677.
- Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017 Nov 15;8(1):1518. View Article
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