Anti-GABA-A Receptor, Gamma 2 Subunit [10F10-C1-B8] Antibody
This IgG2b mouse antibody was generated against amino acids 37-53 of rat GABA-A receptor gamma2 subunit GABRG2 and is specific for the N-terminal extracellular domain, allowing for the detection of surface expressed receptors for live imaging.
Highlights:
- Reacts with GABA-A Receptor Gamma 2 Subunit
- Suitable for Western Blot, Immunoblot, Immunohistochemistry and Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 10F10-C1-B8.
GABA-A receptors are ligand-gated neurotransmitter receptors that function to mediate the fast synaptic inhibition within the brain. They are pentamers, composed from a variety of classes of subunits with gamma being just one class. Each subunit is composed of an extracellular N-terminal domain, four membrane spanning units, and a small extracellular C-terminal segment. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
From the laboratory of Jaideep Kapur, MD, PhD, University of Virginia.
This IgG2b mouse antibody was generated against amino acids 37-53 of rat GABA-A receptor gamma2 subunit GABRG2 and is specific for the N-terminal extracellular domain, allowing for the detection of surface expressed receptors for live imaging.
Highlights:
- Reacts with GABA-A Receptor Gamma 2 Subunit
- Suitable for Western Blot, Immunoblot, Immunohistochemistry and Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 10F10-C1-B8.
GABA-A receptors are ligand-gated neurotransmitter receptors that function to mediate the fast synaptic inhibition within the brain. They are pentamers, composed from a variety of classes of subunits with gamma being just one class. Each subunit is composed of an extracellular N-terminal domain, four membrane spanning units, and a small extracellular C-terminal segment. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
From the laboratory of Jaideep Kapur, MD, PhD, University of Virginia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-GABA-A Receptor, Gamma 2 Subunit [10F10-C1-B8] |
| Antigen: | GABA-A Receptor Gamma 2 Subunit |
| Accession ID: | P18508, NP_899156 |
| Isotype: |
EG1401: IgG2b Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | 10F10-C1-B8 |
| Reactivity: | Reactive against the N-terminal extracellular domain (amino acids 37-53) of the gamma2 subunit of the GABA-A protein in rats |
| Immunogen: | Generated against the gamma2 subunit of the GABA-A protein from rats |
| Species Immunized: | Mouse |
| Epitope: | N-terminal extracellular domain (amino acids 37-53) |
| Purification Method: | Protein G |
| Buffer: |
EG1401: PBS, 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | WB, IF, IHC, IP |
| Concentration: | 1mg/mL |
| Storage: | -20C |
| Shipped: | Cold packs |
For western blot, 1:2,000 dilution recommended.
For IHC, 1:250 dilution recommeneded.
- Joshi S, Sun C, Kapur J. A mouse monoclonal antibody against the gamma2 subunit of GABA-A receptors. Hybridoma. 30(6): 537-42 (2011).
If you publish research with this product, please let us know so we can cite your paper.
