Anti-Caspase 11 (17D9) monoclonal antibody

Caspases are a family of cysteine proteases, that are known to regulate apoptosis. Once a stimulus is recieved by the cell, descrete apoptotic pathways are potentiated by subsets of the caspases that can then activate additional intracellular effectors. Caspase 11 can directly activate caspase 3 under certain pathological conditions. Caspase 11 is also known to be an important activator of caspase 1.

***This product may take 4 to 6 weeks to ship.***

From a laboratory at Harvard University.

Part of The Investigator's Annexe program.

Catalog Number	Product	Description	Price	Order
EF0003	Anti-Caspase 11 (17D9), 100ug	100ug	Price: $237.00	Qty:

Product:	Anti-Caspase 11 (17D9)
Clonality:	monoclonal
Specificity:	Caspase 11 (mouse)
Immunogen:	Bacterial fusion protein (p30)
Rasied in:	Rat
Isotype:	IgG2a
Purity:	Protein G affinity purified
Form:	liquid
Concentration:	0.4 mg/ml
Amount:	100 ug
Applications:	WB, ELISA, IHC
Shipped:	Cold pack
Storage conditions:	Store at 4C

References

Juying Li et al. Flightless-1 regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. JCB, Vol. 181, No. 2, April 21, 2008
Juying Li. Et al. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology, Vol 9, Number3, March 2007
SJ Kang. Et al. Distinct downstream pathways of Caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death and Differentiation(2002) 9, 1115-1125
SJ Kang. et al. Dual Role of Casepase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions. The Journal of Cell Biology, Vol. 149, Number 3, May1, 2000
Suyue Wang. Et al. Murine Caspase-11, an Ice-Interacting Protease, Is Essential for the Activation of ICE. Cell, Vol. 92, 501-509, Feb 20, 1998

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