Cyclic Diguanosine Monophosphate (c-di-GMP)
This Cyclic Diguanosine Monophosphate (c-di-GMP) was chemically synthesized as described in reference 2 below. The compound is highly pure, sterile, and endotoxin free.
c-di-GMP (also known as cyclic diguanylate, cyclic-di-GMP) is a second messenger used in signal transduction in bacteria, important in studies of bacterial virulence, bacterial infectiousness, pathogenesis, vaccine adjuvants (potentially in MRSA vaccines), innate immunity response, bacterial biofilm formation, bacterial cell-cell interactions, and bacterial cell adhesion. Biological activity regulated by c-di-GMP is mediated through binding to many different receptors. Additionally, it has been more recently shown that c-di-GMP induces the production of type I interferons in a STING or DDX41 dependent manner in the mammalian innate immune system.
From the laboratory of Roger A. Jones, PhD, Rutgers University.
Part of The Investigator's Annexe program.
| Chemical Formula: ||C20H24N10O12P2 |
|CAS number: ||61093-23-0 |
| Molecular Weight: ||690 |
| Physical form: ||powder |
| Quality: ||>95% HPLC |
| Source: ||Synthetic |
|UV: ||λmax253nm / ε 23700 / pH7 |
| Solubility: ||c-di-GMP is soluble in water and aqueous buffers |
| Shipped: ||Shipped at room temperature |
| Storage Temp: ||Stable at room temperature; -20C for long term storage |
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- Christen M, Kulasekara HD, Christen B, Kulasekara BR, Hoffman LR, Miller SI. Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division. Science. 2010 June 4. 328(4):1295-97.
- Gaffney BL, Veliath E, Zhao J, Jones RA. One-FlaskSyntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp]Thiophosphate Analogues. Org Lett. 2010 Jun 24. DOI:10.1021/ol101236b.
- Zhao J, Veliath E, Kim S, Gaffney BL, Jones RA.(2009) Thiophosphate analogs of c-di-GMP: impact onpolymorphism. Nucleosides Nucleotides Nucleic Acids.28(5):352-78.
- Zhang Z, Kim S, Gaffney BL, Jones RA. (2006)Polymorphism of the signaling molecule c-di-GMP.J. Am. Chem. Soc. 128(21):7015-24.
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