Anti-TL1A [L4G6] Antibody
![Anti-TL1A [L4G6] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1246_2001202001264012450.jpg "Anti-TL1A [L4G6] Antibody")
This hamster IgG1 monoclonal antibody was generated against recombinant mouse TNF-like ligand 1A (TL1A), and is specific for mouse TL1A.
Highlights:
- Reacts with mouse TL1A (epitope: Blocks binding to tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
- Suitable for FACS, ELISA and Biological Function applications
TNF-like ligand 1A (TL1A), also known as Vascular endothelial growth inhibitor (VEGI) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. The protein belongs to the tumor necrosis factor ligand superfamily, and is a receptor for TNFRSF25 and TNFRSF6B. TL1A mediates activation of NF-kappa-B, and inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis pathways, and is found in endothelial cells but not in B or T cells. TL1Apromotes splenocyte alloactivation. In clinical studies, it has been shown to be strongly associated with inflammatory bowel disease.
From the laboratory of Eckhard R. Podack, MD, PhD, University of Miami.
This hamster IgG1 monoclonal antibody was generated against recombinant mouse TNF-like ligand 1A (TL1A), and is specific for mouse TL1A.
Highlights:
- Reacts with mouse TL1A (epitope: Blocks binding to tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
- Suitable for FACS, ELISA and Biological Function applications
TNF-like ligand 1A (TL1A), also known as Vascular endothelial growth inhibitor (VEGI) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. The protein belongs to the tumor necrosis factor ligand superfamily, and is a receptor for TNFRSF25 and TNFRSF6B. TL1A mediates activation of NF-kappa-B, and inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis pathways, and is found in endothelial cells but not in B or T cells. TL1Apromotes splenocyte alloactivation. In clinical studies, it has been shown to be strongly associated with inflammatory bowel disease.
From the laboratory of Eckhard R. Podack, MD, PhD, University of Miami.
| Product Type: | Antibody |
| Alternative Name(s): | Vascular endothelial growth inhibitor (VEGI), TNF superfamily member 15 (TNFSF15) |
| Antigen: | TL1A-TNF-like ligand 1A |
| Accession ID: | O95150, NM_204524 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | L4G6 |
| Reactivity: | Mouse |
| Immunogen: | MTL1A-MBP (Maltose Binding Protein), Freund's complete and incomplete adjuvant |
| Species Immunized: | Armenian Hamster |
| Epitope: | Blocks binding to TNFRSF25 |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | ELISA, FACS and Biological Function |
| Storage: | -20C |
| Shipped: | Cold packs |
- Fang L, Adkins B, Deyev V, Podack ER. Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med. 2008 May 12;205(5):1037-48.
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