MC-38-MUC-1 Cell Line
The MC-38 MUC-1 Cell Line was derived from a murine colon adenocarcinoma and is engineered to express human Mucin 1, cell surface associated (MUC-1).
Highlights:
- Isolated from colon carcinoma in mice
- Expresses MUC-1
MUC1 or polymorphic epithelian mucin (PEM) is a part of the mucin family, which are glycosylated proteins produced by epithelian tissues. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas.
From the laboratories of Jeffrey Schlom, PhD and James W. Hodge, PhD, MBA, National Cancer Institute/NIH.
The MC-38 MUC-1 Cell Line was derived from a murine colon adenocarcinoma and is engineered to express human Mucin 1, cell surface associated (MUC-1).
Highlights:
- Isolated from colon carcinoma in mice
- Expresses MUC-1
MUC1 or polymorphic epithelian mucin (PEM) is a part of the mucin family, which are glycosylated proteins produced by epithelian tissues. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas.
From the laboratories of Jeffrey Schlom, PhD and James W. Hodge, PhD, MBA, National Cancer Institute/NIH.
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| Product Type: | Cell Line |
| Name: | MC-38-MUC-1 |
| Accession ID: | P15941, CVCL_5I38 |
| Morphology: | Epithelial |
| Source: | Colon Carcinoma |
| Organism: | Murine C57BL6 |
| Biosafety Level: | BSL2 |
| Growth Conditions: | DMEM with 10 % FBS, 2mM glutamine, 0.1mM nonessential amino acids and 1mM sodium pyruvate and 50ug/ml gentamycin sulfate, 300 ug/ml G418 |
| Subculturing: | 1:5, or 1:10 |
| Cryopreservation: | 90% FBS + 10% DMSO |
| Mycoplasma Tested: | Yes |
| Storage: | Liquid nitrogen |
| Shipped: | Dry ice |
- Akagi J, Hodge JW, McLaughlin JP, Gritz L, Mazzara G, Kufe D, Schlom J, Kantor JA. Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell costimulatory molecule B7. J Immunother. 1997 Jan;20(1):38-47. PubMed PMID: 9101412.
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