Anti-p130 Cas (BCAR1) [8G4-E8] Antibody
![Anti-p130 Cas (BCAR1) [8G4-E8] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/981_200120200126299800.jpg "Anti-p130 Cas (BCAR1) [8G4-E8] Antibody")
This mouse IgG2a monoclonal antibody [8G4-E8] was generated against a GST fusion protein corresponding to residues 576-796 of rat p130 Cas and is reactive against human, mouse and rat p130 Cas.
Highlights
- Reacts with human, mouse and rat p130 Cas
- Suitable for Western Blot, Immunoprecipitation and Immunofluorescence applications
Breast cancer anti-estrogen resistance protein 1 (BCAR1, p130 Cas) is ubiquitously expressed adapter protein belonging to the Cas family. It can act as a docking protein containing multiple protein-protein interaction domains and used by many signalling partners. Due to its ability to associate with many signaling partners, p130 Cas/BCAR1 has been shown to play a key role in cell adhesion, migration, apoptosis, hypoxia and mechanical forces. Over expression of p130 Cas/BCAR1 has been identified in several cancer types including breast cancer.
From the laboratories of Amy H. Bouton, PhD and J. Thomas Parsons, PhD, University of Virginia.
Part of The Investigator's Annexe program.
This mouse IgG2a monoclonal antibody [8G4-E8] was generated against a GST fusion protein corresponding to residues 576-796 of rat p130 Cas and is reactive against human, mouse and rat p130 Cas.
Highlights
- Reacts with human, mouse and rat p130 Cas
- Suitable for Western Blot, Immunoprecipitation and Immunofluorescence applications
Breast cancer anti-estrogen resistance protein 1 (BCAR1, p130 Cas) is ubiquitously expressed adapter protein belonging to the Cas family. It can act as a docking protein containing multiple protein-protein interaction domains and used by many signalling partners. Due to its ability to associate with many signaling partners, p130 Cas/BCAR1 has been shown to play a key role in cell adhesion, migration, apoptosis, hypoxia and mechanical forces. Over expression of p130 Cas/BCAR1 has been identified in several cancer types including breast cancer.
From the laboratories of Amy H. Bouton, PhD and J. Thomas Parsons, PhD, University of Virginia.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | p130 Cas |
| Accession ID: | P56945, NM 014567 |
| Molecular Weight: | 130 kDa |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 8G4-E8 |
| Reactivity: | Human, mouse and rat |
| Immunogen: | GST fusion protein corresponding to residues 576-796 of rat p130 Cas |
| Species Immunized: | Mouse |
| Epitope: | AA 576-796 |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, IF, IP |
| Storage: | -20C |
| Shipped: | Cold packs |
- Bouton AH, Burnham MR. Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies. Hybridoma. 1997 Oct;16(5):403-11.
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