Anti-Tau Monoclonal Antibody (PC1C6)
This IgG2a mouse antibody was generated against purified denatured bovine microtubule associated proteins and recognizes human, rat, and bovine Tau1.
Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. The protein interacts with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.
*** This product may take 4-6 weeks to ship ***
From the laboratory of Lester I. Binder, PhD, University of Virginia (now affiliated with Northwestern University).
Part of The Investigator's Annexe program.
| Catalog Number |
Product |
Description |
Price |
Order |
| EG7001 |
Anti-Tau Monoclonal Antibody (PC1C6), 100ug |
100ug |
Price: $351.00 |
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Antigen Name(s):
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Anti-Tau Monoclonal Antibody (PC1C6)
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Immunoglobulin isotype:
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IgG2a
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Clonality:
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monoclonal
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Clone Name:
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PC1C6
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Species Reactivity:
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Recognizes human, rat, and bovine Tau1
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Type of immunogen:
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Generated against purified denatured bovine microtubule associated proteins
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Species immunized:
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balb/c mouse
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Antibody purification method:
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Protein G affinity purified
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Antibody Concentration:
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1 mg/mL
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Tested Applications - WB (Yes/No):
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Yes
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Tested Applications - ELISA:
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No
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Tested Applications - IF (ICC):
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No
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Tested Applications - IHC:
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Yes
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Tested Applications - IP:
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No
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Specificity of Tau-1 in whole rat brain.
Lane A, Coomassie Blue stain of an SDS extract of whole rat brain. Lane B, immunoblot of a lower concentration of the sample in lane A reacted with the Tau-1 monoclonal antibody. Unlike bovine brain, rat brain contains at least six immunoreactive species of tau. Lane C, immunobtot of a twice-cycled microtubule preparation from whole rat brain. Note that two or three polypeptides
(*) are lost during microtubule purification. The numbers to the left represent molecular
weight (Xl0^-3). (Adapted from: Binder LI, Frankfurter A, and Rebhun LI. The distribution of Tau in mammalian central nervous system. J Cell Biol. 101(4):1371-8 (1985).).
References
- Binder LI, Frankfurter A, and Rebhun LI. The distribution of Tau in mammalian central nervous system. J Cell Biol. 101(4):1371-8 (1985).
If you publish research with this product, please let us know so we can cite your paper.
