Dynein Light Chain 1/3 Antibodies
![Anti-Dynein Light Chain 1/3 [10F6-D1-D9] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-Dynein Light Chain 1/3 [10F6-D1-D9] Antibody")
These mouse IgG1 antibodies were generated against dynein light chain and recognize rat and human homologs of both DYNLT1 and DNYLT3 cytoplasmic dynein light chains.
Highlights:
- Reacts with rat and human homologs of both DYNLT1 and DNYLT3 cytoplasmic dynein light chains
- Suitable for Western Blot and Immunofluorescence applications
Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These motor proteins contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (microtubules in the case of the kinesin family and dyneins). In all cell types, dynein is a large protein complex composed of six distinct subunits and is responsible for most intracellular movement toward the minus ends of microtubules. Cytoplasmic dynein has many important roles in transporting membrane bound organelles, including endosomes, lysosomes, and mitochondria. It is also involved in the positioning of the centrosome, the nucleus, and the Golgi. It is comprised of 2 heavy chain polypeptides (DYNC1H1, DYNC2H1), two intermediate chains (DYNC1I1, DYNC1I2), light-intermediate chains (DYNC1LI1, DYNC1LI2) and light chains (DYNLT1, DYNLT3, DYNLRB1, DYNLRB2, DYNLL1, DYNLLl2). Cytoplasmic dynein is also responsible for virus transport to the nucleus, retrograde axonal transport, and microtubule and neurofilament transport.
From a laboratory at University of Virginia.
These mouse IgG1 antibodies were generated against dynein light chain and recognize rat and human homologs of both DYNLT1 and DNYLT3 cytoplasmic dynein light chains.
Highlights:
- Reacts with rat and human homologs of both DYNLT1 and DNYLT3 cytoplasmic dynein light chains
- Suitable for Western Blot and Immunofluorescence applications
Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These motor proteins contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (microtubules in the case of the kinesin family and dyneins). In all cell types, dynein is a large protein complex composed of six distinct subunits and is responsible for most intracellular movement toward the minus ends of microtubules. Cytoplasmic dynein has many important roles in transporting membrane bound organelles, including endosomes, lysosomes, and mitochondria. It is also involved in the positioning of the centrosome, the nucleus, and the Golgi. It is comprised of 2 heavy chain polypeptides (DYNC1H1, DYNC2H1), two intermediate chains (DYNC1I1, DYNC1I2), light-intermediate chains (DYNC1LI1, DYNC1LI2) and light chains (DYNLT1, DYNLT3, DYNLRB1, DYNLRB2, DYNLL1, DYNLLl2). Cytoplasmic dynein is also responsible for virus transport to the nucleus, retrograde axonal transport, and microtubule and neurofilament transport.
From a laboratory at University of Virginia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Dynein Light Chain 1/3 |
| Accession ID: | P51808 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | 10F6-D1-D9 or 6C4-C12-F8 |
| Reactivity: | Rat, human |
| Immunogen: | Generated against dynein light chain |
| Species Immunized: | Mouse |
| Purification Method: | Protein A or A/G affinity purified |
| Buffer: | PBS, 0.05% Sodium Azide |
| Tested Applications: | WB, IF |
| Storage: | -20C |
| Shipped: | Cold packs |
- Lo KW, Kogoy JM, Rasoul BA, King SM, Pfister KK. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. J Biol Chem. 2007 Dec 21;282(51):36871-8. doi: 10.1074/jbc.M705991200. Epub 2007 Oct 27. PMID: 17965411.
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