Anti-LNFPIII/Lewis X (CD15) [E.5] Antibody
![Anti-LNFPIII/Lewis X (CD15) [E.5] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/4088_2001202001283540870.jpg "Anti-LNFPIII/Lewis X (CD15) [E.5] Antibody (supernatant), 5mL")
This mouse IgM monoclonal antibody was generated against carbohydrate and is specific for human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC).
Highlights:
- Reacts with human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC)
- Originally used in S. mansoni research - Also useful in the research involving nematodes and, possibly trematodes
- Recommended for Flow Cytometry applications
Lacto-N-fucopentaose III is an oligosaccharide found in human milk and shown to be involved in the development of the mucosal immune system. LNFPIII contains a Lewis X structure in the oligosaccharide. Lewis X also known as CD15 is an immunological significant molecule that can be expressed in glycoproteins, glycolipids and proteoglycans and has diagnostic relevance in many diseases and is a marker for pluripontent stem cells.
From the laboratory of Donald A. Harn, PhD, University of Georgia.
This mouse IgM monoclonal antibody was generated against carbohydrate and is specific for human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC).
Highlights:
- Reacts with human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC)
- Originally used in S. mansoni research - Also useful in the research involving nematodes and, possibly trematodes
- Recommended for Flow Cytometry applications
Lacto-N-fucopentaose III is an oligosaccharide found in human milk and shown to be involved in the development of the mucosal immune system. LNFPIII contains a Lewis X structure in the oligosaccharide. Lewis X also known as CD15 is an immunological significant molecule that can be expressed in glycoproteins, glycolipids and proteoglycans and has diagnostic relevance in many diseases and is a marker for pluripontent stem cells.
From the laboratory of Donald A. Harn, PhD, University of Georgia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC) |
| Accession ID: | P22083 |
| Isotype: | IgM |
| Clonality: | Monoclonal |
| Clone Name: | E.5 |
| Reactivity: | Human |
| Immunogen: | Carbohydrate |
| Species Immunized: | Mouse |
| Buffer: | Cell Culture supernatant |
| Tested Applications: | Fluorsecent staining for flow cytometry |
| Storage: | -80C |
| Shipped: | Dry ice |
- Srivastava L, Tundup S, Choi BS, Norberg T, Harn D. Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells. Infect Immun. 2014 May;82(5):1891-903.
- Atochina O, Harn D. LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction. Clin Diagn Lab Immunol. 2005 Sep;12(9):1041-9.
- Tundup S, Srivastava L, Norberg T, Watford W, Harn D. A Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway. PLoS One. 2015 Sep 4;10(9):e0137495.
If you publish research with this product, please let us know so we can cite your paper.
